Aging is a universal phenomenon. Every organism in this living world ages with time. Of many factors responsible for aging, diet and food are some of the significant contributors. Advanced Glycation End (AGE) products are one such factor that accumulates during aging and age-related diseases. However, whether exogenous AGE compounds cause aging or not is an area that needs to be explored. Specifically how an organ undergo aging and aging-related phenomena that needs further investigation. Drosophila melanogaster, a well-known model organism, is used to decode aging and age-associated phenomena. In this study, we fed Ribose induced Advanced Glycation End products (Rib-AGE) to D. melanogaster to study the aging mechanism. The Rib-AGE-induced aging will be checked in Drosophila's gut, ecdysteroid, corpora allata and juvenile hormone. Certain natural compounds are known to slow down aging via different pathways.The current study will check the antiaging effect of Piceatannol. First we checked the impact of Rib-AGE on aging using gut as the organ of intrest.We found a series of changes in Rib-AGE-fed flies. Reactive oxygen species (ROS) and Nitric oxide species (NOS) were higher in the Rib-AGE-fed flies, and the antioxidant level was lower. The intestinal permeability was altered. The microorganism load and faecal count were higher inside the gut. The structural arrangement of the gut's microfilament found to be damaged, and the nuclear shape was found to be irregular. Cell death was elevated in comparison to control. The food intake was found to be reduced. The size of the 3^rd instar larvae was comparatively more petite in control than in the Rib-AGE-fed. The relative mRNA expression of the Sirtuin 2 gene of D. melanogaster was downregulated in Rib-AGE-fed flies compared to the control. All these findings strongly suggest that Rib-AGE causes aging and age-related disorders within the gut of Drosophila. Our future study will illucidate the effect of Rib-AGE on ecdysteroid, corpora allata and juvenile hormone. This study will also report the effect of Picetannol on sinking the age induced by feeding of RIB-AGE.