BIOGRAPHY
Over a 25-year scientific career in India and abroad, Prof. Dhiman has published over 70 peer-reviewed articles in esteemed journals, encompassing host-pathogen interactions, mycobacterial pathogenesis, immunology, drug discovery, and host-directed therapies like autophagy and apoptosis. Throughout his distinguished career, he has significantly advanced the understanding of immune responses to Mycobacterium tuberculosis. His PhD research elucidated the role of NF-?B in the apoptosis of mycobacteria-infected cells, differentiating the activation potentials of virulent and avirulent strains. His post-doctoral work highlighted IL-22's role in NK cell-mediated protection during BCG vaccination, emphasizing innate immune responses in tuberculosis control. He has authored more than 10 book chapters and a book entitled "Autophagy Processes and Mechanisms." Prof. Dhiman has collaborated with prominent scientists globally and has been honored with awards such as the Shining Star Award, Laboratory Travel Award, and DST-INSPIRE Faculty Award. As a principal investigator, he has secured over Rs. 170 lakh in funding from prestigious organizations, including DST-SERB, DST-INSPIRE, and DBT. His efforts have significantly advanced his department and institute, exemplified by the establishment of a Confocal Scanning Laser Microscope worth Rs. 2.5 crore for live imaging.
EXPERTISE INFORMATION
Research Group
- Immunology and Molecular Medicine
Areas of Interest
- Host-pathogen interaction in M. tuberculosis infection, Autophagy, Microbial Immunology, Innate and adaptive immunity in tuberculosis
Rohan Dhiman
रोहन धीमान
Professor & Registrar
Life Science
dhimanr@nitrkl.ac.in
0661 - 246 2780
74
PUBLICATIONS8
SPONSORED PROJECTS10
DOCTORAL STUDENTS3
CONTINUING EDUCATIONPERSONAL INFORMATION
Rohan Dhiman
Professor
Life Science
Room Number: MN-246
Department of Life Science, National Institute of Technology Rourkela, Sundargarh, Odisha, India - 769008
Ph.D. (Institute of Microbial Technology, Chandigarh)
To delineate the survival strategy of mycobacteria through antigenic determinants by inhibiting autophagy via miRNA and its significance in host directed therapy. DBT
- Principal Investigator
- 36
- Running Sponsored
Involvement of bacterial cytoskeleton in morphogenesis during biofilm development for xenobiotic degradation. BRNS
- Co-Investigator
- 36
- Running Sponsored
Identification of novel autophagy modulators to augment host directed therapies again mycobacteria. Science & Technology Department,Govt Of Odisha
- Principal Investigator
- 36
- Completed Sponsored
To decipher the epigenietic regulatory mechanism(s) of SOX2 gene in human prostate cancer and self renewal of cancer stem cell. SERB
- Co-Investigator
- 36
- Completed Sponsored
Soybean lectins and their antimycobacterial role by regulating autophagy SERB
- Principal Investigator
- 36
- Completed Sponsored
To study the antimycobacterial role of calcium ionophores by inducing autophagy of mycobacteria infected macrophages DST
- Principal Investigator
- 60
- Completed Sponsored
To study the effect of major immunodominant antigens of mycobacteria on calcimycin induced autophagy in infected macrophages SERB
- Principal Investigator
- 36
- Completed Sponsored
Understanding the marine bacterial biofilm community structure and harnessing the extracellular polymeric substances (EPS) of biofilm for bioremediation and bioprospecting Ministry of Earth Sciences (MoES)
- Co-Investigator
- 36
- Running Sponsored
Total Publications: 74
A. Behura, M. Das, A. Kumar, L. Naik, A. Mishra, D. Manna, S. Patel, A. Mishra, R. Singh, and R. Dhiman,"ESAT-6 impedes IL-18 mediated phagosome lysosome fusion via microRNA-30a upon Calcimycin treatment in mycobacteria infected macrophages", International Immunopharmacology, vol.101, no.108319, Elsevier, November 2021, 10.1016/j.intimp.2021.108319 Article
A. Kumar, L. Naik, S. Patel, M. Das, Dev. K. Nayak, A. Mishra, A. Mishra, R. Singh, A. Behura, and R. Dhiman,"Ac-93253 inhibits intracellular growth of mycobacteria in human macrophages by inducing apoptosis in mitochondrial-dependent manner", Biochimica et Biophysica Acta - General Subjects, vol.1867, no.9, pp.13, Elsevier, September 2023, 10.1016/j.bbagen.2023.130425 Article
A. Behura, L. Naik, S. Patel, M. Das, A. Kumar, A. Mishra, Dev. K. Nayak, D. Manna, A. Mishra, and R. Dhiman,"Involvement of epigenetics in affecting host immunity during SARS-CoV-2 infection", Biochimica et Biophysica Acta - Molecular Basis of Disease, vol.1869, no.166634, pp.13, Elsevier, March 2023, 10.1016/j.bbadis.2022.166634 Article
L. Naik, S. Patel, A. Kumar, A. Ghosh, A. Mishra, M. Das, Dev. K. Nayak, S. Saha, A. Mishra, R. Singh, A. Behura, and R. Dhiman,"4-(Benzyloxy)phenol-induced p53 exhibits antimycobacterial response triggering phagosome-lysosome fusion through ROS-dependent intracellular Ca2+ pathway in THP-1 cells", Microbiological Research, vol.282, no.127664, Elsevier 2024, 10.1016/j.micres.2024.127664 Article
S. Patel, L. Naik, M. Das, Dev. K. Nayak, P. K. Dandsena, A. Mishra, A. Kumar, V. R. Dirisala, A. Mishra, S. Das, R. Singh, A. Behura, and R. Dhiman,"Furamidine-induced autophagy exerts an anti-mycobacterial effect in a SIRT1-pAMPK-FOXO3a-dependent manner by elevation of intracellular Ca2+ level expression", Microbiological Research, vol.290, pp.127976, Elsevier, January 2025, 10.1016/j.micres.2024.127976 Article
Host-pathogen interaction: present and future perspective (Online) Life Science (Conference)
- Coordinator
- 24 Sep 2020 - 25 Sep 2020
- Brochure
Host-pathogen interaction: present and future perspective (Online) Life Science (Conference)
- Coordinator
- 24 Sep 2020 - 25 Sep 2020
- Brochure
Techniques to Understand Autophagic Processes in Mammalian Systems (TUAPMS) Life Science (Workshop)
- Coordinator
- 26 Feb 2020 - 01 Mar 2020
- Brochure
- LS100 : Biology {Theory}
- LS1001 : Biology {Theory}
- LS204 : Plant Science {Theory}
- LS2403 : Plant Science {Theory}
- LS303 : Genetics {Theory}
- LS311 : Cell and Cellular Techniques {Theory}
- LS3405 : Genetics {Theory}
- LS6002 : Advanced Immunology {Theory}
- LS602 : Advanced Immunology {Theory}
- LS2092 : Life Science Laboratory- II {Practical}
- LS274 : Plant Science Laboratory {Practical}
- LS3093 : Life Science Laboratory- III {Practical}
Ph.D. Students [10]
Understanding the Role of Ac-93253 Iodide in Apoptosis as an Anti-mycobacterial Response in Macrophages
Ashish KumarEnrolled: Jul 2018Graduated : Mar 2024Supervisor
Stimulation of Autophagy by Soybean Lectin (SBL) and Its Antimycobacterial Response in Human Macrophages
Abtar MishraEnrolled: Jan 2017Graduated : Oct 2022Supervisor
Mechanistic Insight on the Role of ESAT-6 in Modulating Host Defensive Pathways through MicroRNA-30a in Mycobacteria Infected Macrophages
Assirbad BehuraEnrolled: Jul 2016Graduated : Dec 2021Supervisor
Modulation of Autophagy and its Effect on Intracellular Mycobacteria by Calcimycin
Shradha MawatwalEnrolled: Jan 2015Graduated : Jun 2019Supervisor
Evolutionary Adaptations and Host Immune Modulation by Salmonella Typhimurium
Diana PradhanEnrolled: Jul 2014Graduated : Nov 2019Co-Supervisor
Secondary metabolites and its antimycobacterial role
Pramathesh Kumar DandsenaEnrolled: Jul 2024ContinuingSupervisor
Mycobacterial Immunology and host-directed therapy
Dev Kiran NayakEnrolled: Feb 2022ContinuingSupervisor
MICROBIOLOGY
Mousumi DasEnrolled: Sep 2020ContinuingSupervisor
Molecular Biology,Immunology,Cell Biology,Cancer Biology,Micro Biology
Salina PatelEnrolled: Sep 2020ContinuingSupervisor
Host pathogen interaction in Tuberculosis and role of autophagy in antimycobacterial response
Lincoln NaikEnrolled: Jul 2019ContinuingSupervisor
Memberships / Fellowships
- The Indian Science Congress Association, Indian Immunology Society,