Course Details
Subject {L-T-P / C} : CY5201 : Bioinorganic Chemistry { 3-1-0 / 4}
Subject Nature : Theory
Coordinator : Prof. Rabindra Kumar Behera
Syllabus
Introduction: Metal ions essential for biological functions, Basic coordination chemistry in biology, Biological ligands for metal ions, Metal ions specificity Ion-transport and Signal transduction:Ion (Na+ and K+) transport: Ion Channels & Pump, Ionophore Ca2+: Cell Signalling (Calmodulin) and Heart Pumping (Troponin C) Mg2+: ATP Hydrolysis O2 storage and transport: myoglobin/hemoglobin and Hemocyanin (Cu)/Hemerythrin (Resonance Raman Spectra) O2 activation and toxicity/detoxification:Cytochrome P450, Peroxidase, Catalase, Super Oxide Dismutase (SOD) Fe transport, storage and acquisition: Transferrin, Ferritin (Resonance Raman and Mossbauer Spectra) and Siderophore Electron Transfer: Cytochromes, Fe-S Cluster, and Plastocyanin (Cu) Marcus Theory ATP Synthesis: Photosynthesis, and Respiration: Cytochrome C Oxidase (Fe & Cu) Nitrogen Fixation: Nitrogenase (Fe & Mo) Zn2+ (Lewis Acidity): Carbonic Anhydrase, Carboxy Peptidases, ADH and Zinc Finger protein Cu2+ /Cu+ redox systems, AAO, Group Transfer: Vitamin B12 (Co) Metals in Health.
Course Objectives
- The course is designed to provide an overview of the biological needs and the behaviors of Inorganic Elements linked to several metalloproteins and enzymes.
Course Outcomes
The students would be able to understand the importance of bio-active elements in daily life. The students will be able to apply the knowledge gained in this course to explain several problems associated with bio-inorganic chemistry research.
Essential Reading
- Bertini, I. Gray, H. B. Stiefel, E. I. Valentine, J. S., Biological Inorganic Chemistry: Structure and Reactivity, University Science Books , 2007
- Robert Chrichton, Biological Inorganic Chemistry: A New Introduction to Molecular Structure and Function, , Elsevier , 2012
Supplementary Reading
- Wolfgang Kaim and Axel Klein, Bio-inorganic Chemistry, Wiley , 2013
- L. Que. Jr., Physical Methods in Bioinorganic Chemistry, University Science Books
Journal and Conferences
- JBIC, Metallomics, JBC, JIB
- Video Lectures by Dr. R.K. Behera A.N. Koshla Center for Technology Enabled Learning: http://nitrkl.ac.in/Oldwebsite/Academic/1Department/TEL/VideoLecture.aspx