Course Details
Subject {L-T-P / C} : BM4106 : System Biology { 3-0-0 / 3}
Subject Nature : Theory
Coordinator : Prof. Nandini Sarkar
Syllabus
Introduction to cellular and population-level systems biology with an emphasis on synthetic biology, modeling of genetic networks, cell-cell interactions, and evolutionary dynamics Molecules of life: Genes and proteins Transcription networks Regulation of gene transcription Network motifs in transcription regulation Network motifs in signaling networks Origins of biological robustness Optimal gene circuits Kinetic modeling of biochemical reactions Kinetic modeling of large scale biomolecular networks Integration of regulatory and metabolic networks Biological networks and drug development.
Course Objectives
- To understand modelling of genetic networks
- To understand kinetic modelling of biochemical reactions and biomolecular networks
- Understanding integration of metabolic and regulatory network
- applying system biology approaches in drug development
Course Outcomes
Applying system approaches to address biological questions
Essential Reading
- Uri Alon, An Introduction to Systems Biology: Design Principles of Biological Circuits, Chapman & Hall/CRC Press
- M.A. Nowak, Evolutionary Dynamics: Exploring the Equations of Life, Belknap Press, 2006.
Supplementary Reading
- Alberts, Bruce, Essential Cell Biology, Garland Science, 2009
- Darren J. Wilkinson, Stochastic Modelling for Systems Biology, CRC Press