Course Details
Subject {L-T-P / C} : BM2502 : Thermodynamics and Biochemical Reaction { 3-0-0 / 3}
Subject Nature : Theory
Coordinator : Dr. Prasoon Kumar
Syllabus
Introduction, Energy Transformation, system and surroundings, Internal energy, Work, heat capacity, First law of thermodynamics, energy conservation in the living organisms. The second law of thermodynamics, entropy, isothermal systems, Protein denaturation, The third law and biology, Irreversibility and life.
Gibbs free energy – reversible processes, phase transitions, chemical potential, effect of solutes on boiling points and freezing points, ionic solutions, equilibrium constant, chemical coupling, redox reactions. Applications of Gibbs free energy (photosynthesis, substrate cycling, osmosis, dialysis, membrane transport, enzyme substrate interaction, protein solubility, stability and dynamics, ELISA, non equilibrium thermodynamics etc). Statistical thermodynamics, binding equilibria.
Reaction kinetics – Introduction, Rate of reaction, rate constant and order of reaction, First and second order reaction, temperature effects, collision theory, transition state theory, electron transfer kinetics, enzyme kinetics, inhibition, reaction mechanism of lysozyme, hydrogen exchange, protein folding and pathological misfolding, polymerization, muscle contraction and molecular motors. The frontier of biological thermodynamics.
Course Objectives
- To understand the basic and applied thermodynamics principles
- To understand how the thermodynamics principles help in understanding the functions of biological systems
- To understand how reaction engineering and thermodynamics principles are applicable to the functioning of biological macro-molecules
- To learn the principles of statistical thermodynamics and understand the role of statistical thermodynamics in explaining the behavior of biological thermodynamics
Course Outcomes
Students would be able to <br />1) understand thermodynamics as engineering tool for biological engineers <br />2) understand the difference between engineering and biological thermodynamics <br />3) understand applying thermodynamics principles to biological systems from molecular to system level <br />4) apply principles of statistical mechanics to uncover the behavior of ensemble of molecules <br />5) understand principles behind molecular dynamics, monte-carlo, lattice –boltzman and other simulations to understand behavior of biomolecules
Essential Reading
- Donald T Haynie, Biological Thermodynamics,, 2nd Edi, Cambridge University Press, 2013.
- D. J. Haynie, Biological thermodynamics,, Cambridge, 2008
Supplementary Reading
- P.K Nag, Engineering Thermodynamics, Tata McGraw-Hill Education, 2005.
- M. L Shular and F. Kargi, Bioprocess Engineering - Basic concepts, 3rd Edi. Prentice Hall, 2017. Sub.