Course Details
Subject {L-T-P / C} : BM6431 : Advanced Bioinformatics { 3-0-0 / 3}
Subject Nature : Theory
Coordinator : Prof. Mukesh Kumar Gupta
Syllabus
History, aim and scope of bioinformatics in biotechnology and medical engineering. Bio-databases: classification, information retrieval, Search Engines versus Databases. Major bioinformatic recourses: NCBI, EMBL and DDBJ, Data mining and knowledge-discovery. Bio-algorithms, computing and tools: File formats, Pattern matching, Sequence alignments, Gene prediction methods, Molecular Phylogeny, Data visualization, Molecular viewer. Protein 3D structure and classification for bioinformatics. Protein structure prediction and modelling. Bioinformatics in computer-aided Drug designing. Modelling of biomolecular systems, Simulation, statistics and biochemical networks
Course Objectives
- To provide basis understanding of bioinformatics in biotechnology and medical engineering
- To solve bioindustrial problems using modern bioinformatic tools for gene annotation, functional proteomics, molecular phylogeny etc.
- To train on the development and use of bioinformatic softwares and provide logistics to the development of modern bioinformatic tools for bio-molecular simulations, 3-D protein modelling, computer-aided drug design and molecular docking
Course Outcomes
1. Understand the aim and scope of bioinformatics in biotechnology and medical engineering. <br />2. Gain knowledge on bio-algorithms, bio-databases, information retrieval, data mining, file formats, molecular viewer etc. <br />3. Analyze and provide solution to bioindustrial problems using modern bioinformatic tools for gene annotation, functional proteomics, molecular phylogeny etc. <br />4. Use bioinformatic softwares and provide logistics to the development of modern bioinformatic tools for bio-molecular simulations, 3-D protein modelling, computer-aided drug design and molecular docking
Essential Reading
- • Pevsner J, Bioinformatics and Functional Genomics, Wiley-Blackwell, USA , ISBN: 978-81-265-3834-8
- • Lesk AM, Introduction to Bioinformatics, Oxford University Press
Supplementary Reading
- Mount DW, Bioinformatics: Sequence and Genome Analysis, Cold Spring Harbor Laboratory Press
- Attwood T and Parry-Smith D, Introduction to Bioinformatics, Prentice Hall