Course Details
Subject {L-T-P / C} : CY5105 : Medicinal Chemistry { 3-0-0 / 3}
Subject Nature : Theory
Coordinator : Prof. Gokarneswar Sahoo
Syllabus
Introduction to medicinal chemistry: concepts, Biomolecules as drug targets, Proteins and enzymes, Drug receptors, Genetic components as targets, working principle, transport and metabolism of drugs, Prodrugs and drug delivery systems, Drug design and QSAR, Drug discovery and development, Combinatorial chemistry, Structure-activity relationships, Specific drug families, Anteoplastic agents: Cancer chemotherapy, role of alkylating agents and antimetabolites in treatment of cancer, anti-metabolites, carcinolytic antibiotics, mitotic inhibitors, Antibiotics: Constitution and synthesis of penicillins, chloramphenicol, tetracyclic and streptomycine Antimalerials: Synthesis and properties of 8-amino-quinolone derivatives- pamaquine, primapune, pentaquinr, isopentaquine, 4-aminoquinolone derivatives-santoquine, camaquine, acridine derivatives-mepracrine, azacrin, Cardiovascular Drugs: Antihypertensive and hypotensive drugs, antiarrhythmic agents, vasopressor drug direct acting arteriolar dilators. Biological action of methyldopa, propranolol hydrochloride, amyl nitrate, sorbitrate, verapamil, Atenolol. Antihistaminic agents: Ethylene diamine derivatives, amino alkyl ether analogues, cyclic basic chain analogues. Antifertility agents: General antifertility agents. Diuretics: Mercurial diuretic, Non mercurial diuretics (Thiazides, carbonic-anhydrase inhibitors, xanthine derivatives, pyrimidine diuretics and osmotic diuretics.
Course Objectives
- The course intends to educate the students about the "Chemistry behind drugs' interaction and influence with biological target".
- The course would prepare students to make a career in Pharmaceutical Chemistry
Course Outcomes
1) Students will learn the chemistry behind the development and activity of drugs. <br />2) Students will have a clear understanding on "Interaction of drugs with biological targets" and the role of medicinal chemists and chemistry in drug design.
Essential Reading
- G. L. Patrick, An Introduction to Medicinal Chemistry, Oxford University Press , 2013
- S.N. Pandeya and J. R. Dimmock, Introduction to Drug Design, New Age International , 2006
Supplementary Reading
- Richard B. Silverman and Mark W. Holladay, The Organic Chemistry of Drug Design and Drug Action, Academic Press , Third Edition
- Charles O. Wilson, Ole Gisvold, Robert F. Doerge, Textbook of Organic Medicinal and Pharmaceutical Chemistry, Wiley , 1977
Journal and Conferences
- Book Review: Textbook of Organic Medicinal and Pharmaceutical Chemistry, Edited by Charles O. Wilson, Ole Gisvold, Robert F. Doerge. https://doi.org/10.1002/jps.2600661052