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Current research
Controlled Delivery of Dexamethasone to the Intestine from Poly (vinyl alcohol) - Poly (acrylic acid) Microspheres Containing Drug-Cyclodextrin Complexes: Influence of Method of Preparation of Inclusion Complex. Ms. Subhraseema Das and Dr. Usharani Subuddhi* Dept. of Chemistry.

D
examethasone (DX) is highly active in the treatment of virtually every type of B-cell malignancy; however significant side-effects are invariably associated with it thereby warranting a delivery system that can deliver DX at a controlled rate at the therapeutic level at a specific site. pH-Sensitive microspheres comprised of poly (vinyl alcohol) and poly (acrylic acid) were synthesized for delivery of DX to the intestine. The microspheres
exhibited negligible drug release in the simulated gastric fluid whereas significant release in the intestinal fluid. Thus the microspheres could be effectively employed for the oral delivery of DX and their pH sensitivity could be exploited for the intestinal delivery. The microspheres containing the freeze-dried inclusion complexes were found to be the best of the lot for achieving a much controlled release of DX. Funded by: DST, India. More in: RSC Adv., 2014, 4, 24222–24231 (List of Research)

NEW SPONSORED PROJECT
Evolution of Nanoporosity and Nanostructure in Polymer .......
PI: Prof. Shantanu Kumar Behera
Sponsor: SERB
 
Adams completion and Cocompletion
PI: Prof. Akrur Behera
Sponsor: DAE
 
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