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-A.P.J. Abdul Kalam

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Current research
Syntheses and structural investigation of some alkali metal ion-mediated LVVO2− (L2− = tridentate ONO ligands) species: DNA binding, photo-induced DNA cleavage and cytotoxic activities” Rupam Dinda*, Subhashree P. Dash, Department of Chemistry

E
ight alkali metal ion-mediated dioxidovanadium(V), [{VVO2L1−6}A(H2O)n]∝, complexes for A = Li+, Na+, K+ and Cs+, containing tridentate aroylhydrazonate ligands coordinating via ONO donor atoms, are described. All the complexes were successfully characterized by elemental
analysis, IR, UV-Vis, NMR spectroscopy and X-ray crystallography The dioxidovanadium(V) complexes were found to exhibit DNA binding activity due to their interaction with CT-DNA by the groove binding mode, with binding constants ranging from 103 to 104 M−1. Complexes 1–8 were also tested for DNA nuclease activity against pUC19 plasmid DNA. Finally, the in vitro antiproliferative activity of all complexes was assayed against the HeLa cell line. (more in Dalton Trans., 2014,43, 10139-10156) (List of Research)

NEW SPONSORED PROJECT
Electromagnetic welding (EMW) coil design & characteriz .......
PI: Dr. Mohammed Rajik Khan
Sponsor: BRNS
 
Design and development of a Bidirectional DC-DC Convert .......
PI: Prof. Susovon Samanta
Sponsor: SERB, DST
 
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