Seminar Details

Seminar Title
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Underlying mechanism of photocatalytic nanoformulations-mediated immunomodulatory and cancerous or anticancerous behaviors
Seminar Type
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Registration Seminar
Department
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Life Science
Speaker Type
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Student
Speaker Name
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SONALI JENA ( RollNo : 519LS2014)
Date  &  Time
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16 Jun 2021  10:30 AM
Venue
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Online-MS Team (Code: d11rxq0)
Contact
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Prof. Suman Jha
Abstract
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In cancer biology, metabolic alterations in tumor cells, to adopt the challenging physiological condition, are an emerging attraction for investigation. The augmented expression of Hypoxia-inducible factor-1α (HIF-1α) in the tumor microenvironment (TME), mainly due to tumor growth, plays a key role in the progression of cancer and has been recognized as a novel theranostic target. Since HIF -1α is the master transcriptome regulator of TME and being stabilized by various chaperones like HSP90, HSP70, etc., we are proposing to explore the effect of different nanoformulations on normal and cancerous cell line by following the expression of HIF1α and other heat shock responses. Recent studies reported that photocatalytic nanoparticles with lower energy band gap exerted higher oxidative stress to the cells, which leads to chromosomal aberration, DNA fragmentation, cell cycle arrest, etc. The arrested cells are then left with two options, either they can undergo autophagy-mediated recovery or apoptotic cell death. Till now, the exact mechanism behind this autophagy-mediated recovery and the fate, whether it becomes cancerous or not is unexplored. Thus, the main focus of the study is to understand the unexplored underline mechanism of likely nanoformulation-mediated inflammatory response and potential cancerous or anti-cancerous behavior. Some photocatalytic nanoparticles are found to be induce inflammation by activating M1 macrophage response. So, this study would basically focus on the inflammatory response arises in presence of photocatalytic nanoparticle in vitro.